The 2nd International Conference of Deep Space Sciences (ICDSS 2025) will be held in Hefei, the capital city of Anhui Province, from 7th to 11th April 2025. It is jointly organized by University of Science and Technology of China (USTC) and the Insitute of Deep Space Sciences at the Deep Space Exploration Laboratory (DSEL). China will carry out more deep space exploration missions in the next 10 to 15 years. The fourth stage of its lunar exploration program has been approved, including Chang'e-6, Chang'e-7, and Chang'e-8. The next step of the planetary exploration program is also fixed. China will implement Tianwen-3 for Mars sample return, and Tianwen-4 for Jupiter system exploration. Meanwhile, more deep space exploration missions, e.g., for the Sun, the heliopause, icy planets, and exoplanets, are in the plan. The International Conference of Deep Space Sciences brings scientists worldwide to discuss new developments in deep space sciences. The conference consists of a series of topical sessions. On behalf of the Organizing Committee, we feel deeply honoured to invite you to submit abstracts and participate in ICDSS 2025. New proposals for topical sessions are also welcome (Please contact skts@ustc.edu.cn).